MDI Biological Laboratory

Archive for: heart disease

Citizen Scientists Support Doctoral Research

Arsenic, lead, and uranium, naturally occurring contaminants in some groundwater, are not uncommon in New England, where significant portions of the population rely on wells for drinking water. Long-term or acute exposure to these contaminants can lead to multiple types of cancer, heart disease, diabetes, and more. Federal and state guidelines regulate the maximum contaminant…

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Making a Mouse More Like an Axolotl: How James Godwin’s Discoveries Are Helping Science ‘Pull the Levers of Regeneration’

Science is now inching closer to the answer thanks to new research by MDI Biological Laboratory scientist James Godwin, Ph.D. Following in the laboratory’s tradition of using comparative biology to gain insights into human health, Godwin has compared the molecular mechanisms governing regeneration in a highly regenerative salamander to those in the mouse, which has…

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New Horizons for the Treatment of Diabetic Complications

Chronic complications of diabetes are the leading cause of morbidity and mortality not only in the western world but worldwide. The metabolic changes caused by diabetes, especially hyperglycemia (high blood sugar levels), can lead over time to damage in the circulation system of the diabetic patient. Subsequent ischemia (inadequate blood supply reaching organs) occurs, as…

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Seeing Science Fiction Become Reality

As a child growing up in East Millinocket, Maine, Scott MacKenzie was a huge fan of science and science fiction. One of the first magazines he ever subscribed to was Scientific American; one of the first books he ever read was science fiction. Now he can read about the research he has supported as the…

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Research Models Less Traveled By

The following interview with Kevin Strange, Ph.D., president of the MDI Biological Laboratory, is excerpted from Eureka, a blog serving the CRO (contract research organization) industry. Launched by Charles River Labs in 2012, the site is a way for scientists to connect and share big ideas on the cutting-edge bench science driving drug discovery and development, particularly in the areas of preclinical safety and assessment, pharmaceutical manufacturing and animal research models.

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MDI Biological Laboratory President Kevin Strange, Ph.D., Speaks to Maine Startups Insider About Novo Biosciences

The following post is excerpted from a “Founder Forum” interview with Kevin Strange, Ph.D., about Novo Biosciences that originally appeared in the online publication, “Maine Startups Insider (MSI).”

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What If Stimulating Regeneration Were As Simple As Taking a Drug?

This excerpt from the MDI Biological Laboratory’s biannual news magazine, “Breaking Through,” describes the institution’s pioneering approach to regenerative medicine.

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This Is Why: Dean Read

In this excerpt from the MDI Biological Laboratory’s biannual news magazine, “Breaking Through,” MDI Biological Laboratory donor and volunteer Dean Read of Bar Harbor discusses what motivates him to give.

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MDI Biological Laboratory Scientists Awarded Patent for Potential New Heart Disease Drug

The U.S. Patent and Trademark Office has announced that it will grant a patent to MDI Biological Laboratory scientists Voot P. Yin, Ph.D., and Kevin Strange, Ph.D., and their collaborator Michael Zasloff, M.D., Ph.D., for use of the small molecule MSI-1436 to stimulate the repair and regeneration of heart tissue.

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