MDI Biological Laboratory

Archive for: Genome

Will CRISPR/Cas9 be the Catalyst that Revolutionizes Human Health?

Associate professor, Dustin Updike, Ph.D., is internationally recognized for using CRISPR/Cas9 in his research. CRISPR/Cas9 is a gene-editing technology revolutionizing scientific research and experimental therapies in human health. A genome, the term used to describe all of an organism’s DNA as a whole, is like a blueprint laying out the directions for an organism’s body…

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Bioinformatics: The Importance of Training the Trainer

MDI Biological Laboratory is beyond pleased to be hosting the upcoming Bioinformatics T3: Train the Trainer from June 26 until July 3 – not only because this is a vital and expanding field or because of our passion for educating the next generation of amazing scientists – but because we are able to welcome folks back to…

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Part III: Meet the Computational Biology Core

(Read part one or part two of the series.)  For this entry into our ongoing discussion of the MDI Biological Laboratory Computational Biology Core, I want to take a step back and, rather than talk about the specifics of the science, instead talk about who we are, what we do, and why it is so…

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Bioinformatics Part II: What do my genome-scale measurements of gene expression mean?

Graphical representation of differential gene expression for a single gene.  The red triangles represent measurements of replicate treated samples, and the black diamonds represent matched control samples.  Differential expression of this gene is determined by a statistical analysis of the separation between expression levels in treated and control, compared to the variation within each group…

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Part I: Computational Biology is vital to modern research

But what exactly is it and why does science need it? The typical interpretation of this figure is that the arrows represent the “flow of information”: that DNA is capable of self-replication (represented by the circular arrow); that the information stored in DNA is activated by first being transcribed to RNA (resulting in an RNA…

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