MDI Biological Laboratory

Archive for: Chronic Kidney Disease

Pioneering New Kidney-Grafting Techniques

New research published in the journal Bioengineering was led by former visiting scientists Leif Oxburgh, D.V.M., Ph.D. and Denise Marciano, M.D., Ph.D., and the MDI Bio Lab’s Iain Drummond, Ph.D.  Drummond calls the challenge of getting lab-grown kidney tissue to link with an organism's circulatory system and function properly a "plumbing problem." 

Continue Reading

Visiting Scientist Nishad Jayasundara, Ph.D.: Solving the Riddle of the Mysterious Kidney Ailment Plaguing Farmers Around the World

This is the third in a series of posts describing how collaborations between MDI Biological Laboratory faculty members and visiting scientists are advancing scientific progress.

Continue Reading

Chalk Talks Still Going Strong

For over a century, MDI Biological Laboratory has hosted short research visits and sabbaticals for academic and industry scientists. Throughout the summer and fall, our Visiting Scientist program continues to flourish as we welcome a series of researchers whose work dovetails with our own faculty’s. For many of us, no better moment captured the magic of MDIBL’s collaborations than our long running tradition of the popular summer Chalk Talk series.

Continue Reading

Research by Iain Drummond, Ph.D., Brings Science Closer to Kidney Replacement Tissue

We all know our kidneys are charged with filtering our blood – an astonishing 52 gallons of it a day. But how does that actually happen? It turns out that it’s not unlike what one might imagine.

Continue Reading

National Kidney Month

March is #NationalKidneyMonth and we’re celebrating MDI Biological Laboratory’s longstanding and close connection to renal physiology, starting with Homer Smith, D. Sc., (1895-1962) the renowned scientist who made many significant contributions to the field – including identifying how the kidney works. He spent a period of his career at MDIBL and his determination and curiosity...

Continue Reading

New Horizons for the Treatment of Diabetic Complications

Chronic complications of diabetes are the leading cause of morbidity and mortality not only in the western world but worldwide. The metabolic changes caused by diabetes, especially hyperglycemia (high blood sugar levels), can lead over time to damage in the circulation system of the diabetic patient. Subsequent ischemia (inadequate blood supply reaching organs) occurs, as...

Continue Reading

From the Bench to the Bedside – A Long Affair with Diabetic Nephropathy

All my life I have been interested in studying the complications of diabetes. Diabetes has two sides: on the one hand it is a metabolic disorder that effects glucose levels, and the metabolism is treated by medications that lower glucose. On the other hand, over time diabetes leads to damaging changes in the vascular bed,...

Continue Reading

Report from the 2016 American Society of Nephrology Kidney Week: Using Stem Cells and Organoids to Build a New Kidney

Nephrologists have always been interested in basic biology. At the MDI Biological Laboratory, scientists have been making major scientific contributions to the understanding of the molecular mechanisms of renal tubules and their implications for salt and water balance — and hence their effect on disease — for nearly a century. In recent years, the focus...

Continue Reading

Seeking to Regenerate a Kidney from Scratch

In this interview in Regenerative Medicine Network, an online publication, Hermann Haller, M.D., an MDI Biological Laboratory faculty member and director of the Department of Nephrology and Hypertension at Hannover Medical School in Hanover, Germany, discusses the quest to replace lost or damaged kidney tissue, or replace the kidney entirely.

Continue Reading