Scientific Resources

The Bioinformatics Core collaborates with scientists to provide essential data management and analysis tools along with experimental design consulting using continually updated workflows. The Core also specializes in custom database and analysis software development.

A major initiative of the Core is the development of the Comparative Models of Regeneration Database (RegenDB) to provide a systems-level view of regenerative biology and stem cell self-renewal. This resource is part of the MDI Biological Laboratory’s Center of Biomedical Research Excellence (COBRE) that focuses on regeneration, tissue repair, and aging.

The Core also serves as a statewide resource for the Maine IDeA Network for Biomedical Research Excellence (ME-INBRE) program in comparative functional genomics by providing essential consulting and training in bioinformatics.

Biomedical scientists benefit from access to complex microscopes and sophisticated imaging technologies. Due to the accelerating rate of imaging technology development, turnover and high costs, it is difficult for individual research labs to afford, master and maintain them. The MDI Biological Laboratory and NIGMS-funded Maine IDeA Network of Biomedical Research Excellence (INBRE) have made significant investments in developing a state-of-the-art Light Microscopy Facility (LMF) that is accessible to researchers at MDIBL, Maine and beyond.

As the leading light microscopy facility in Maine, our goal is excellence in user service, research support, training, and community engagement. A strong emphasis has been put on education; the LMF-MDIBL developed the first Maine microscopy course open to all levels, from students to project investigators, in Maine for no cost.

Thanks to all the efforts from the LMF-MDIBL user community, the facility has won multiple imaging contests in recent years, allowing us to show the quality of the training, equipment and expertise we can offer to anyone who needs help to answer their research questions.

The Animal Resources Core provides extensive expertise and facilities for aquatic model husbandry and experimental use. The Core is equipped with Aquaneering aquatic systems in 2,000 square feet of dedicated space and responsible for the husbandry of Zebrafish, African turquoise killifish and axolotl year-round. In the summer months, they extend their care to additional invertebrate and non-mammalian vertebrates needed for courses and visiting scientists, such as cane toads, turtles, salmon, local killifish, goldfish, and xenopus (African clawed frogs).

Expertise and resources are available to perform:

• Custom platforms for antisense morpholino and cDNA microinjection
• Fully automated Zebralab workstation to conduct high content imaging and behavioral assays
• iWorx ECG system for cardiotoxicity studies
• Adaptable and scalable drug screening and assay development