A team of scientists led by James Godwin, Ph.D., of the MDI Biological Laboratory has come a step closer to unraveling the mystery of why salamanders can regenerate while adult mammals cannot with the discovery of differences in molecular signaling that promote regeneration in the axolotl, a highly regenerative salamander, while blocking it in the adul…
A team led by Iain Drummond, Ph.D., director of the Kathryn W. Davis Center for Regenerative Biology and Aging, has identified the signaling mechanisms underlying the formation of podocytes, which are tiny, highly specialized cells in the glomerulus, the cluster of blood vessels in the kidney where waste is filtered. The discovery opens the door to the development of therapies to replace or regenerate these cells, which are vital to ridding the body of toxins.
The MDI Biological Laboratory has announced that it has received a grant of $3.14 million over five years from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), an institute of the National Institutes of Health (NIH), for the development of artificial kidney tissue to replace human kidney tissue that is lost to disease or injury.
Prayag Murawala, Ph.D., a scientist at the MDI Biological Laboratory, has received a grant of $332,000 to address the problem of tendon injury. He is seeking to determine if the same cellular and molecular mechanisms responsible for regenerating tendons during limb regeneration in the axolotl, or Mexican salamander, also come into play during tendon regen…
The MDI Biological Laboratory has announced that Romain Madelaine, Ph.D., has been appointed to the faculty as an assistant professor. He will study neuron and muscle tissue regeneration at the laboratory’s Kathryn W. Davis Center for Regenerative Biology and Aging.
A team of scientists at the MDI Biological Laboratory led by James A. Coffman, Ph.D., is shedding new light on the gene regulatory pathways activated by cortisol, a hormone secreted in response to stress. Their research helps explain why exposure to chronic stress early in life shortens lifespan and contribute to age-related chronic diseases later in life — long after the source of stress has been removed.…
The development of a new imaging technique by Prayag Murawala, Ph.D., of the MDI Biological Laboratory and his collaborators, however, enables unprecedented insight subcellular structures, tissues, organs and even whole organisms, and — because of its wide applicability — broadens the range of animal models that can be studied, processes that can be explored and biological questions that can be addressed.
Research by scientists at the MDI Biological Laboratory in Bar Harbor, Maine, is opening up new approaches to promote tissue regeneration in organs damaged by disease or injury.
The MDI Biological Laboratory has announced that Prayag Murawala, Ph.D., has joined the faculty as an assistant professor. Murawala will study appendage regeneration in the axolotl, or Mexican salamander (Ambystoma mexicanum), a champion of regeneration that can regenerate virtually any body part.
Thanks to a $75,000 grant from The Cotswold Foundation, the MDI Biological Laboratory will add the African turquoise killifish (Nothobranchius furzeri) to its growing roster of animal models, thus strengthening the institution’s longstanding tradition of engaging in comparative research to gain an understanding of the mechanisms involved in aging and regeneration.