207-288-9880 ext 444
159 Old Bar Harbor RD
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Salisbury Cove, ME 04672
Chronic early life stress can have lifelong effects that predispose an individual to a variety of inflammatory diseases and more rapid aging, a phenomenon known as “developmental programming” of health and disease. We are investigating the mechanisms underlying these effects, focusing on (1) how chronic exposure to the stress hormone cortisol during early life programs immune system development, and (2) the long-term effects of that programming on the body’s capacity for tissue repair and regeneration. We are using zebrafish as a model system to investigate these issues, as the cortisol-mediated stress response is conserved between zebrafish and humans, and zebrafish are exceptionally amenable to detailed mechanistic studies of both early development and adult regeneration.
MDI Scientists Investigating Ways to Slow Aging
In The Media · July 3, 2016
Maine Scientist Seeks Keys to How Sea Urchins Avoid Aging Process
In The Media · June 1, 2016
MDIBL Scientists Study ‘Ocean Methuselahs’ to Learn About Aging
In The Media · May 26, 2016
Do Sea Urchins Hold the Secret to Anti-Aging?
In The Media · May 26, 2016
Is Ageing Inevitable? Sea Urchins Could Hold the Key to Living Forever
In The Media · May 26, 2016
Is Aging Inevitable? Not Necessarily for Sea Urchins
Press Release · May 24, 2016
Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation. Hartig, E.I., Zhu, S., King, B.L, and Coffman, J.A. (2016). Biology Open, in press.
An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo. Rizzo, F., Coffman, J.A., and Arnone, M.I. (2016). Dev. Biol., in press.
Comparative biology of tissue repair, regeneration, and aging. Coffman, J.A., Rieger, S., Rogers, A.N., Updike, D.L, and Yin, V.P. (2016). npj Regen. Med., 1: 16003.
Maintenance of somatic tissue regeneration with age in short- and long-lived species of sea urchins. Bodnar, A.G. and Coffman, J.A. (2016). Aging Cell, in press.
Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals. Arenas-Mena, C. and Coffman, J.A. (2015). Dev. Dyn., 244: 1193-1201.
Gene expression changes associated with the developmental plasticity of sea urchin larvae in response to food availability. Carrier, T.J., King, B.L., and Coffman, J.A. (2015). Biological Bulletin, 228: 171-180.
On the meaning of chance in biology. Coffman, J.A. (2014). Biosemiotics 7: 377-388.
Oral-aboral axis specification in the sea urchin embryo IV. Hypoxia radializes embryos by preventing the initial spatialization of nodal activity. Coffman, J.A., Wessels, A., DeSchiffart, C., and Rydlizky, K. (2014). Dev. Biol. 386: 302-307.
Developmental cis-regulatory analysis of the cyclin D gene in the sea urchin Strongylocentrotus purpuratus. McCarty, C.M., and Coffman, J.A. (2013). Biochem. Biophys. Research Comm. 440: 413-418.
Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division. Robertson, A.J., Coluccio, A., Jensen, S., Rydlizky, K., and Coffman, J.A. (2013). Biology Open, 2: 472-478.
Global Insanity: How Homo sapiens Lost Touch with Reality while Transforming the World. Coffman, J.A. and Mikulecky, D.C. (2012). Emergent Publications (ISBN 9781938158049).
Nodal-mediated epigenesis requires dynamin-mediated endocytosis. Ertl, R.P., Robertson, A.J., Saunders, D., and Coffman, J.A. (2011). Dev. Dyn. 240: 704-711.
Oxygen, pH, and oral-aboral axis specification in the sea urchin embryo. Coluccio, A.E., LaCasse, T.J., and Coffman, J.A. (2011). Mol. Rep. & Dev. 78: 68.
On causality in non-linear complex systems: the developmentalist perspective. Coffman, J.A. (2011). In: Philosophy of Complex Systems (Cliff Hooker, ed.): pp. 287-309. North Holland/Elsevier, Oxford, UK (ISBN 9780444520760).
The evolution of Runx genes. II. The C-terminal Groucho recruitment motif is present in both eumetazoans and homoscleromorphs but absent in a haplosclerid demosponge. Robertson, A.J., Larroux, C., Degnan, B.M., and Coffman, J.A. (2009). BMC Research Notes 2: 59.
Oral-aboral axis specification in the sea urchin embryo III. Role of mitochondrial redox signaling via H2O2. Coffman, J.A., Coluccio, A., Planchart, A., and Robertson, A.J. (2009). Dev. Biol. 330: 123-130.
Is Runx a linchpin for developmental signaling in metazoans? Coffman, J.A. (2009). J. Cellular Biochem. 107: 194-202.
Mitochondria and metazoan epigenesis. Coffman, J.A. (2009). Semin. Cell Dev. Biol. 20: 321-329.
Runx expression is mitogenic and mutually linked to wnt activity in blastula-stage sea urchin embryos. Robertson, A.J., Coluccio, A., Knowlton, P., Dickey-Sims, C., and Coffman, J.A. (2008). PLoS One 3: 11.
Mitochondria, redox signaling, and axis specification in metazoan embryos. Coffman, J.A. and Denegre, J.M. (2007). Dev. Biol. 308: 266-280.
CBF-beta is a facultative Runx partner in the sea urchin embryo. Robertson, A.J., Dickey-Sims, C., Ransick, A., Rupp, D.E., McCarthy, J.J., and Coffman, J.A. (2006). BMC Biol. 4: 4.
Developmental ascendency: from bottom-up to top-down control. Coffman, J.A. (2006). Biological Theory 1 (2):165-178.
The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus. Robertson, A.J., Croce, J., Carbonneau, S., Voronina, E., Miranda, E., McClay, D.R. and Coffman, J.A. (2006). Dev. Biol. 300: 321-334.
The genome of the sea urchin Strongylocentrotus purpuratus. Sodergren E., Weinstock G. M., Davidson E. H., Cameron R. A., Gibbs R. A., Angerer R. C., Angerer L. M., Arnone M. I., Burgess D. R., Burke R. D., Coffman J.A., et al. (The Sea Urchin Genome Sequencing Consortium) (2006). Science 314: 941-952.
- Shusen Zhu, M.S., Research Assistant
- Ellen Hartig, B.S., B.A., Research Assistant