Dr. Haller also uses zebrafish embryos to analyze the molecular mechanisms how embryonic kidneys become connected to the aorta and whole body circulation. The Haller Lab is generating transgenic “marker” fish, which allow them to study the cellular movements in the embryonic fish and analyze how the circulation and the embryonic tissue interact and eventually make blood flow in the kidneys possible. To test their observations, they generate zebrafish deficient (or overproducing) of the factors responsible for vascularization.
Lastly, they use this information in a three-dimensional microcirculatory chamber to stimulate their stem-cell derived organoids to become vascularized. Once blood flow has been established, their organoids can grow and become small kidneys. In addition, the three-dimensional microcirculatory chambers can also be used to study the “plumbing” of embryonic tubules to a waste system – thereby generating a cellular system to grow kidneys from adult stem cells.
- MDIBL’s Work in 2022 Includes a New Way To Prevent COVID-19 Infection Blog · January 13, 2023
- 2022 MDI Biological Laboratory Publications Blog · January 13, 2023
- A Springboard for Science Achievement: Biomedical Education on Maine’s Coast Blog · December 14, 2022
- Haller Honored in Germany Blog · November 17, 2022
- Summer of Fun and Futures: Life in the Haller Lab Blog · Winter/Spring 2022
- Kiyan Y, Schultalbers A, Chernobrivaia E, Tkachuk S, Rong S, Shushakova N, Haller H. Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate. Sci Rep. 2022 Oct 7;12(1):16878. doi: 10.1038/s41598-022-20973-3. PMID: 36207386; PMCID: PMC9542452.
- Haller H. The Embarrassment of Riches: Combining SGLT2 Inhibitors and Nonsteroidal Mineralocorticoid Antagonists for the Treatment of Diabetic Kidney Disease. Am J Nephrol. 2021 Sep 16;52(8):605-607. doi: 10.1159/000516214. Epub ahead of print. PMID: 34530423.
- Idowu TO, Etzrodt V, Pape T, Heineke J, Stahl K, Haller H, David S. Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo. Intensive Care Med Exp. 2021 Aug 2;9(1):38. doi: 10.1186/s40635-021-00402-x. PMID: 34337671; PMCID: PMC8326239.
- M.D., Free University of Berlin
- Yale University School of Medicine