Dr. Haller also uses zebrafish embryos to analyze the molecular mechanisms how embryonic kidneys become connected to the aorta and whole body circulation. The Haller Lab is generating transgenic “marker” fish, which allow them to study the cellular movements in the embryonic fish and analyze how the circulation and the embryonic tissue interact and eventually make blood flow in the kidneys possible. To test their observations, they generate zebrafish deficient (or overproducing) of the factors responsible for vascularization.
Lastly, they use this information in a three-dimensional microcirculatory chamber to stimulate their stem-cell derived organoids to become vascularized. Once blood flow has been established, their organoids can grow and become small kidneys. In addition, the three-dimensional microcirculatory chambers can also be used to study the “plumbing” of embryonic tubules to a waste system – thereby generating a cellular system to grow kidneys from adult stem cells.
- Summer of Fun and Futures: Life in the Haller Lab Blog · Winter/Spring 2022
- There is Always Something New: A COVID-19 Update Blog · Winter/Spring 2022
- MDI Biological Laboratory President Elected to German Academy of Sciences Press Release · August 20, 2021
- The COVID-19 pandemic: science’s finest hour RegMedNet · September 11, 2020
- Ultomiris Approved in Europe to Treat Children and Adults with aHUS aHUS News · July 9, 2020
- Haller H. The Embarrassment of Riches: Combining SGLT2 Inhibitors and Nonsteroidal Mineralocorticoid Antagonists for the Treatment of Diabetic Kidney Disease. Am J Nephrol. 2021 Sep 16;52(8):605-607. doi: 10.1159/000516214. Epub ahead of print. PMID: 34530423.
- Idowu TO, Etzrodt V, Pape T, Heineke J, Stahl K, Haller H, David S. Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo. Intensive Care Med Exp. 2021 Aug 2;9(1):38. doi: 10.1186/s40635-021-00402-x. PMID: 34337671; PMCID: PMC8326239.
- Fleig SV, Konen FF, Schröder C, Schmitz J, Gingele S, Bräsen JH, Lovric S, Schmidt BMW, Haller H, Skripuletz T, von Vietinghoff S. Long-term B cell depletion associates with regeneration of kidney function. Immun Inflamm Dis. 2021 Jul 29. doi: 10.1002/iid3.499. Epub ahead of print. PMID: 34324242.
- M.D., Free University of Berlin
- Yale University School of Medicine