Lloyd Cantley, M.D.
C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology; Vice Chair, Research; Co-director of Education, Yale Center for Clinical Investigation
The kidney tubules are particularly susceptible to injury due to the hypoxic nature of the renal medulla. In response to injury, the tubules initially undergo both necrotic and apoptotic cell death, followed by a reparative phase that can, in many cases, lead to effective repair and restoration of function. In humans however, this repair can be ineffective, leading to fibrosis, loss of function and chronic renal failure.