The TNFAIP8 Gene Family in Inflammation and Cancer
The broad objective of my laboratory is to develop comparative zebrafish models to better understand the biological processes that govern inflammation and cancer. To facilitate their application, we perform conserved gene synteny analyses to unwind gene histories that are convoluted by two rounds of early vertebrate genome duplication, and in the case of the teleosts, a third round of whole genome duplication. In this seminar, I will discuss the evolutionary origins of the vertebrate TNFAIP8 family, whose genes have been linked to inflammation and cancer. I will also describe my work applying the zebrafish model to study the roles members of the TNFAIP8 gene family play in immunity and cancer.