Beth Dumont, Ph.D.
The Jackson Laboratory
The broad objective of the Dumont research group is to understand the causes of variation in the very mechanisms that generate genetic diversity. Their current work focuses on homologous recombination, a key determinant of multilocus genetic variation. They integrate phylogenetic perspectives, cytogenetic methods, and genomic analyses in effort to understand the genetic and evolutionary basis of variation in recombination rate. Previously, they demonstrated that closely related house mouse subspecies exhibit marked differences in recombination rates, and showed that much of this variation is explained by a transgressive, large-effect, X-linked recombination rate modifier. In this seminar, Dr. Dumont will summarize these earlier findings and present recent work on the fascinating evolutionary dynamics of crossover rate control in this system.