In the first part of the talk, I will describe different strategies to investigate mechanisms by which dietary restriction extends lifespan using flies. This will include the use of genetics, genomics and GWAS on natural populations of Drosophila.
In the 2nd part, I will describe a C. elegans model with elevated α-dicarbonyls (α-DCs) that shows pathologies reminiscent of diabetes.TRPA1 is a conserved sensor for α-DC stress and activates Nrf2 to mediate α-DC detoxification. This is mediated by conserved glyoxylases, GLO1 and DJ1 downstream of the TRPA1-Nrf2 pathway. A phenotypic drug screen for peripheral neuropathy compounds that activate TRPA1-Nrf2 to rescue α-DC pathologies in worms and mammals.
Dr. Kapahi is a Professor at the Buck Institute for Research on Aging