Jennifer Trowbridge, Ph.D.
Discovery of Cellular and Molecular Targets to Extend Hematopoietic Healthspan
The long-term goal of my laboratory is to develop novel approaches to extend hematopoietic healthspan during aging. In my research program, I consider healthspan extension in the context of improving regenerative function of aged hematopoietic stem and progenitor cells while at the same time preventing hematologic neoplasms initiated within these cellular compartments. My seminar will highlight key progress towards our goal, including our discoveries that 1) functional hematopoietic decline occurs by middle age, 2) alterations in multipotent progenitor cells, in addition to hematopoietic stem cells (HSCs), contribute to functional hematopoietic decline, 3) during transformation, the identity of the cell-of-origin that sustains an oncogenic event (i.e. HSC versus multipotent progenitor versus lineage-committed progenitor) directly impacts tumor aggressiveness, and 4) the aging bone marrow (BM) microenvironment provides a selective growth advantage for HSC clones at risk of transformation. My seminar will focus on these topics and discuss new, unpublished data related to these themes.
Support for this seminar is provided by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103423.