Ulrich Kintscher, M.D.
Charité – Universitaetsmedizin Berlin, Institute of Pharmacology
How adipose tissue regulates cardiac function – from mice and flies
Adipose tissue lipolysis has recently been identified as a crucial regulator of cardiac function. Our work is focused on the characterization of the rate-limiting enzyme ATGL (Adipose Triglyceride Lipase) in adipose tissue and its role as a “remote” regulator of physiological and pathophysiological cardiac function. For this, we use mouse models and Drosophila melanogaster. The seminar will cover the physiology of enzymatic lipolysis, in particular in adipose tissue, its relevance for systemic lipid metabolism, the function of ATGL, and will discuss recent results on the interaction between adipose tissue and heart function. In this context, D. melanogaster will be introduced as a model system to study cardiac function and organ crosstalk.