Development after embryogenesis often requires remodeling of existing tissues. This tissue remodeling is accomplished through carefully orchestrated changes in cell shape, movement, growth and death. Tissue repair and regeneration also require activation of remodeling mechanisms. However, how these distinct cellular processes are coordinated during tissue remodeling remains poorly understood. We study the genetic control of Drosophila metamorphosis, a stage when tissue remodeling transforms a crawling larva into a flying adult. We have identified hundreds of lethal mutations that specifically disrupt metamorphosis. Among these mutations, we study those required for control of growth and death. Most of these metamorphosis-specific mutations map to novel genes, suggesting that studying these genes will provide new insights into the regulation of tissue development and homeostasis.
EventsScientific Seminar – Arash Bashirullah, Ph.D.