We will be hosting this Science Café online.
The topic of the MDI Science Café for Monday, July 12, 2021 will be “ReBuilding Kidneys,” presented by Iain Drummond, Ph.D., MDIBL Professor and Director, Kathryn W. Davis Center for Aging and Regeneration.
For the past century, MDIBL has been a crossroads for investigators who made the original discoveries on how the kidney works, taking advantage of marine fish that taught us key lessons about human kidney function. Now, kidney research at MDIBL stands on the shoulders of these giants and aims to understand how to make and incorporate new kidney tissue to address the challenges of chronic kidney disease and organ replacement. Turning again to the fish, we have discovered how kidney stem cells can make and engraft new kidney tissue after injury as a model for how to promote human stem cell-derived kidney tissue engraftment and organ replacement. As part of the NIH ReBuilding a Kidney consortium, MDIBL continues to forge new knowledge in kidney function and regeneration.
Iain Drummond received his Ph.D. from the University of California Berkeley for work on ionic signaling and the Drosophila heat shock response. His postdoctoral work at Northwestern University Medical School and the University of Chicago focused on gene regulation in Development and Kidney Cancer (Wilms tumor). From 1996-2019, Dr. Drummond was an Associate Professor in Medicine and Genetics at Harvard Medical School / MGH and Director of the Harvard Stem Cell Institute Kidney program. His lab established the zebrafish as a genetic system for discovering mechanisms of kidney development, disease, and regeneration. His work has revealed new genes required for cilia function in organogenesis and in human Primary Ciliary Dyskinesia, established the role of collective cell migration in nephron morphogenesis, discovered new pathways underlying kidney nephrotic syndrome, revealed cellular mechanisms linked to Polycystic Kidney Disease gene functions, and developed the zebrafish pronephros as an in vivo system to evaluate pathogenicity of human gene sequence polymorphisms. Now at the Mount Desert Island Biological Laboratory as Director of the Kathryn W. Davis Center for Aging and Regeneration, his lab studies 1) Vascular/epithelial interactions in kidney morphogenesis, 2) Genetic compensation for cilia gene mutations and 3) Growth factor mechanisms of stem cell-based kidney regeneration and how this can be translated to human cell-based therapy for kidney failure.
Our live online Zoom presentations will be recorded and uploaded for those who cannot make the live session. Please note, when Zoom records, it captures the audience as well as the presenter. If you do not wish to be recorded, please turn off your video camera. Audio will still be available.
MDI Science Cafés are offered in fulfillment of the MDI Biological Laboratory’s mission to promote scientific literacy and increase public engagement with science. The popular events offer a chance to hear directly from speakers about trends in science.
We ask attendees to please preregister online so that we can send you the link to the online presentation.