Dr. Ashley Seifert is Assistant Professor at the University of Kentucky.
Dr. Seifert and his lab are trying to understand the molecular mechanisms that regulate and direct the regenerative response to injury and how these mechanisms are curtailed in non-regenerating systems. Patterning, growth, and cellular differentiation are integrated during regeneration and development, but it remains largely unknown if organ regeneration recapitulates embryonic development or executes its own unique program in response to injury. Using different animal models and organ systems like the skin, digit and limb they are testing how regeneration diverges from the typical scarring response in mammals. In a more clinical context, they try to apply the current understanding of how tissue regeneration occurs in its natural state to develop new approaches to reduce fibrosis and scarring.
The thirty-fifth Kinter Lecture is given in memory of William B. Kinter, Ph.D., an investigator at the MDI Biological Laboratory from 1963 until his untimely death in 1978. Kinter’s interest in the effect of toxic compounds in the environment led to landmark papers on the effect of pesticides on eggshell thinning in birds. Studies of basic physiological effects of environmental pollutants, including crude oil, on the molecular and cellular level occupied him primarily until his death. Kinter’s own contributions, as well as those of his colleagues, were instrumental in shaping this branch of research at the MDI Biological Laboratory.