A major goal in regenerative medicine is to understand and ultimately facilitate our body’s ability to repair itself. Enrique Amaya, Ph.D., is investigating the molecular and cellular mechanisms responsible for scarless wound healing and tissue regeneration in frog embryos and tadpoles. He and his colleagues have shown that regenerating tadpole tails exhibit a sustained production of reactive oxygen species (ROS) during the entire regenerative response. Genetic and pharmacological approaches (including the addition of antioxidants) aimed at lowering ROS levels resulted in impaired tail regeneration. These findings were unexpected, as antioxidants are often thought to be beneficial to health. More recently, Dr. Amaya has found remarkable parallels in the induction, maintenance, and role of reactive oxygen species during tissue regeneration and early embryonic development. Thus, he postulates that the sustained production of ROS following injury promotes a return to an embryonic-like state of cellular oxidation, which facilitates growth factor signaling and tissue growth.
EventsInvited Seminar: A role for reactive oxygen species in appendage regeneration and early embryonic development — Enrique Amaya, Ph.D.