Postdoctoral trainees will perform experiments using physiological models, mechanisms of organic anion transport and calcium signaling in isolated hepatocytes, studies of the enterohepatic circulation, mechanisms of diarrhea and gastric secretion. Confocal microscopy will be used in isolated cell preparations to follow excretion of organic anions and calcium signaling. Modern molecular biology approaches will be used to identify specific transport proteins and bioinformatic approaches will be used to analyze respective genes and gene sets, including mutations which disrupt these processes and result in clinical disease.
Fellows will benefit from close interactions with senior investigators in Liver and GI physiology and pathophysiology who will guide them through the performance of the experiments, share meals, and take the time to discuss their career goals. Fellows will benefit enormously by working closely with other fellows from different programs and sharing their insights into Liver and GI research.
The course is organized around several laboratory modules, including in-depth bioinformatics components, and separate sessions on “Responsible Conduct of Research” and “How to write a paper and get it accepted in Hepatology or Gastroenterology”.
- Organic anion transport and secretion – determinants of bile formation
- Physiologic Imaging in liver cells and tissues
- Enterohepatic circulation
- Mechanisms of Intestinal secretion
- Mechanisms of Gastric secretion
Participants will complete three of the rotations over the six-day course. The first day of each rotation involves intensive experimental work, and the second day involves analysis and presentation of the work to the entire conference group.
tuition amount will be announced as soon as our pending funding applications are completed.
- James L. Boyer, M.D.Ensign Professor of Medicine; Emeritus Director, Liver CenterYale University School of Medicine
- Shi-Ying Cai, DScSenior Research ScientistYale University School of Medicine
- Paul A. Dawson, Ph.D.Professor, Gastroenterology, Department of PediatricsEmory University School of Medicine
- Joel Graber, Ph.D.Senior Research ScientistThe Jackson Laboratory
- Mateus Tavares Guerra, Ph.D.Research ScientistYale University School of Medicine
- Susan Hagen, Ph.D.Associate Professor, SurgeryHarvard Medical School
- Supriya Kulkarni, Ph.D.Associate Research ScientistYale University School of Medicine
- Michael H. Nathanson, M.D., Ph.D.Gladys Phillips Crofoot Professor of Medicine and Cell BiologyYale University School of Medicine
- Patricio Silva, M.D.Professor of Medicine, Section of Nephrology, Hypertension, and Kidney TransplantationTemple University School of Medicine
- Carol Soroka, Ph.D.Senior Research ScientistYale University School of Medicine
This course’s long term objectives include:
- Enhancing the research capacity of medical residents
- Augmenting their potential as future investigators
- Improving their ability to function as effective educators
- Encouraging them to consider a career in academic hepatology or gastroenterology
- Encouraging them to enroll in fellowship training programs in these disciplines