
Postdoctoral trainees will perform experiments using classical physiological models such as determinants of bile secretion in the isolated perfused skate liver, mechanisms of organic anion transport and calcium signaling in isolated hepatocytes, studies of the enterohepatic circulation in everted gut sacs from skate and hagfish, mechanisms of diarrhea with chloride secretion from the shark rectal gland and gastric section in the frog stomach. Confocal microscopy will be used in isolated cell preparations to follow excretion of organic anions and calcium signaling. Modern molecular biology approaches will be used to identify specific transport proteins and bioinformatic approaches will be used to analyze respective genes and gene sets, including mutations which disrupt these processes and result in clinical disease.
Fellows will benefit from close interactions with senior investigators in Liver and GI physiology and pathophysiology who will guide them through the performance of the experiments, share meals, and take the time to discuss their career goals. Fellows will benefit enormously by working closely with other fellows from different programs and sharing their insights into Liver and GI research.
The course is organized around several laboratory modules, including in-depth bioinformatics components, and separate sessions on “Responsible Conduct of Research” and “How to write a paper and get it accepted in Hepatology or Gastroenterology”.
- Organic anion transport and secretion – determinants of bile formation
- Physiologic Imaging in liver cells and tissues
- Enterohepatic circulation
- Mechanisms of Intestinal secretion
- Mechanisms of Gastric secretion
Participants will complete three of the rotations over the six-day course. The first day of each rotation involves intensive experimental work, and the second day involves analysis and presentation of the work to the entire conference group.
Course Director
- James L. Boyer, M.D.Ensign Professor of Medicine; Emeritus Director, Liver CenterYale University School of Medicine
Faculty
- Nadia A. Ameen, M.B.B.S.Associate Professor of Pediatrics (Gastroenterology) and of Cellular and Molecular PhysiologyYale School of Medicine
- Paul A. Dawson, Ph.D.Professor, Gastroenterology, Department of PediatricsEmory University School of Medicine
- Susan Hagen, Ph.D.Associate Professor, SurgeryHarvard Medical School
- Benjamin L. King, Ph.D.Assistant Professor of BioinformaticsUniversity of Maine
- Michael H. Nathanson, M.D., Ph.D.Gladys Phillips Crofoot Professor of Medicine and Cell BiologyYale University School of Medicine
- Paul J. Planet, M.D., Ph.D.Assistant Professor of PediatricsColumbia University College of Physicians and Surgeons
- Patricio Silva, M.D.Professor of Medicine, Section of Nephrology, Hypertension, and Kidney TransplantationTemple University School of Medicine
Sunday, September 6 | ||
4:00-6:00pm | Pick up keys to housing units | Dining Hall |
6:00pm | Welcome Dinner | Dining Hall |
7:00pm | Course Orientation | Maren Auditorium |
Monday, September 7 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 1 | Training Lab |
12:00pm | Lunch | Dining Hall |
1:00pm | Bioinformatics – Orientation Session I | Dahlgren Hall |
2:30pm | Rotation 1 continued | Training Lab |
6:00pm | Dinner | Dining Hall |
Tuesday, September 8 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 1 continued | Training Lab |
12:00pm | Lunch | Dining Hall |
12:30pm | Large Lab Meeting | Dahlgren Hall |
1:30pm | Bioinformatics Session II | Dahlgren Hall |
3:00pm | Free Time | |
6:30pm | Dinner | Dining Hall |
Wednesday, September 9 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 2 | Training Lab |
12:00pm | Lunch | Dining Hall |
1:00pm | Bioinformatics Session III | Dahlgren Hall |
2:30pm | Rotation 2 continued | Training Lab |
6:00pm | Dinner | Dining Hall |
7:00pm | Rotation 2 continued | Training Lab |
Thursday, September 10 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 2 continued | Training Lab |
12:00pm | Lunch | Dining Hall |
12:30pm | Large Lab Meeting | Dahlgren Hall |
1:30pm | Bioinformatics Session IV | Dahlgren Hall |
3:00pm | Free Time | |
6:30pm | Dinner | Dining Hall |
Friday, September 11 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 3 | Training Lab |
12:00pm | Lunch | Dining Hall |
1:00pm | Bioinformatics Session V | Dahlgren Hall |
2:30pm | Rotation 3 continued | Training Lab |
6:00pm | Dinner | Dining Hall |
7:00pm | Rotation 3 continued | Training Lab |
Saturday, September 12 | ||
7:30am | Self-serve breakfast | Dining Hall |
8:30am | Rotation 3 continued | Training Lab |
12:00pm | Lunch | Dining Hall |
12:30pm | Large Lab Meeting & course evaluation | Dahlgren Hall |
2:30pm | Free Time | |
6:00pm | Lobster Dinner | Dining Hall |
Sunday, September 13 | check out 9:00am | |
until 9:30am | Self-serve breakfast | Dining Hall |
On-Campus Housing
Included in tuition. Housing is assigned. Please call 207-288-9880 ext 102 if you have any questions. Subject to availability.
Cottage-style accommodations are available with water front views. Our Cottages sleep 4-5 and are complete with full bathroom, kitchens, living room, high speed wireless internet, and parking.
Dormitory style cottage accommodations are available with double occupancy and single rooms, shared bathrooms, fully equipped kitchens, common room, high speed wireless internet, and parking.
Our on-campus housing is within walking distance of all campus facilities (Note: campus grounds include wooded terrain). Please visit our Housing Website to view our accommodations. Campus Map
Available funding will cover course tuition, room, and all meals. (Travel not included)