Biomedical Innovation Course
iCARB: Immersion in Comparative Aging and Regenerative Biology 2019
Location: MDI Biological Laboratory (travel information)
2019 iCARB Course Schedule and Flyer
This innovative two week immersion course will be a blend of regeneration and aging models, comparative biology and nexus experiments, lectures and seminars.
Within this dynamic environment each student will: 1) characterize and compare regenerative potential across a wide array of species including: planaria, zebrafish, Hydra, mouse, axolotl, and the African turquoise killifish; 2) investigate changes in regenerative potential during aging; 3) combine microsurgical methods with state of the art histology and molecular analysis; and 4) join a growing network of colleagues studying the cross-roads between regeneration and aging.
For graduate students, postdoctoral fellows, and career scientists interested in the nexus of regeneration and biology research.
Applications are open. Complete applications will be reviewed on a rolling basis until the course has filled, at which time a waiting list will be maintained.
MDI Biological Laboratory is located on Mount Desert Island near Acadia National Park and the popular vacation destination of Bar Harbor, Maine.
Maine Center for Biomedical Innovation, MDI Biological Laboratory
Tuition
2019 tuition $4,000.00
Includes:
All course materials, laboratory supplies, double occupancy housing and meals
Fellowship funding is available to support tuition and may be requested in the online application. No travel funds are available.
Partners
Course Directors
Aric Rogers, Ph.D.Assistant ProfessorMDI Biological Laboratory
Voot P. Yin, Ph.D.Associate Professor and Director of Scientific ServicesMDI Biological Laboratory
Course Faculty and Invited Speakers
Elizabeth Duncan, Ph.D.Assistant ProfessorUniversity of Kentucky
James Godwin, Ph.D.Assistant ProfessorThe Jackson Laboratory/MDI Biological Laboratory
Vera Gorbunova, Ph.D.Doris Johns Cherry Professor, Professor of Biology, Associate Professor of OncologyUniversity of Rochester
Joel H. Graber, Ph.D.Senior Staff Scientist, Director of Computational Biology and Bioinformatics CoreMDI Biological Laboratory
Itamar Harel, Ph.D.Primary InvestigatorThe Hebrew University of Jerusalem
Celina Juliano, Ph.D.Assistant Professor of Molecular and Cellular BiologyUniversity of California, Davis
Malcolm Maden, Ph.D.ProfessorUniversity of Florida
James Monaghan, Ph.D.Associate ProfessorNortheastern University
Ashley Seifert, Ph.D.Assistant ProfessorUniversity of Kentucky
2019 iCARB: immersion in Comparative Aging and Regenerative Biology Short Course Schedule
Note: Breakfast is self serve each day in the Dining Hall
As of 7/19/19, subject to change
July 20, 2019 Saturday
5 PM Student arrival, check-in at Dining Hall, early arrivals can wait in the lounge with open wifi.
6-7 PM Dinner—Dining Hall
7-9PM Introduction, Voot Yin and Aric Rogers, MDIBL tour and mixer — MCBI
July 21, 2019 Sunday
8-10AM Breakfast on your own—Dining hall
10-11AM Course introduction by Voot and Aric—blending the themes of regeneration and aging–MCBI
11-noon Pit Talk, Celina Juliano and hydra regeneration—MCBI
Noon-1PM Lunch in Dining Hall
1-4PM Lab: Hydra experiments
4-6PM Free time
6-7 PM Dinner
July 22, 2019 Monday
9-10 AM Pit Talk, Ashley Seifert and Spiny mouse regeneration (mammals) and immune system—MCBI
10-noon Lab: Histology techniques the value to understanding regeneration
12-1PM Lunch in dining hall
2-6PM Lab: Hydra regeneration
Tissue processing and histology
4-5PM Cserr Lecture: Vera Gorbunova: “Mechanisms of Longevity in Long-Lived Mammals”–Maren auditorium
5-6PM Speaker Reception—Maren Foyer
6-8PM Dinner with Dr. Gorbunova—Dining Hall
Discussion point: comparative aging in mammals and the intersection of regenerative capacity
July 23, 2019 Tuesday
9-10AM Pit Talk, Itamar Harel, African killifish and regenerative capacity decline during aging—MCBI
10-noon Lab: African killifish regeneration
12-1PM Lunch in dining hall
1-2-PM Open discussion with faculty—MCBI
2-6PM Lab: African killifish regeneration
Continuation of hydra experiments
6-7PM Dinner in dining hall
7-9PM Lab: Imaging with light and confocal microscopy—MCBI
July 24, 2019 Wednesday
9-10AM Pit Talk, Itamar Harel—History of regeneration —MCBI
10-noon Lab: planaria, RNAi and markers of regeneration
12-1PM Lunch in dining hall
1-4PM Lab: Planaria experiments
Imaging regeneration on the confocal
Continuation of experiments
4-5PM Kinter Lecture: Itamar Harel, “Past, Present and Possible Futures of Regeneration Research”—Maren auditorium
5-6PM Speaker Reception—Maren Foyer
6-8PM Dinner with Dr. Harel—Dining hall
Discussion point: immortality and scientific imagination
July 25, 2019 Thursday
9-10AM Pit Talk, Beth Duncan, planaria regeneration and RNAi—MCBI
10-noon Lab: Check on experiments
12-1PM Lunch in dining hall
1-6PM Free time. Options: Bar Harbor visits; kayaking in Frenchman’s Bay; hiking in Acadia National Park (bag lunches available)
6-7PM Dinner
7-9PM Discussion Point: cross species comparison among model systems during spinal cord regeneration. Merging modern techniques with traditional model systems—advances and limitations of each system, CRISPRS, making transgenics—Dining Hall
July 26, 2019 Friday
9-10 Pit Talk, Joel Graber, RNA-sequencing and bioinformatic analyses–MCBI
10-10:30 Pit Talk, Voot Yin, MSI-1436 and regeneration–dataset set that serves as the background for RNA-seq analysis–MCBI
10:30-12 Lab module: Bioinformatics and analysis of MSI-1436 dataset
12-1 Lunch
1-4PM Lab: Continue bioinformatics module
Check in on experiments
4-5PM Pit talk, Dr. Rogers, aging research and the impact of C. elegans-MCBI
6-7PM Dinner in dining hall
7-9PM Networking panel discussion with faculty
Roundtables on ethics, teaching and research around regenerative and developmental biology—MCBI
July 27, 2019 Saturday
9-10AM Pit talk, James Monaghan, axolotl limb regeneration,–MCBI
10-noon Lab: axolotl limb regeneration
Noon-1 Lunch-dining hall
1-6PM Lab: axolotl limb regeneration
Imaging of regeneration
6-7PM Dinner in dining hall
July 28, 2019 Sunday
9-11AM Student presentation (10 minutes each)
11-12 Break
12-1PM Lunch-Dining Hall
1-2PM Pit Talk, Voot Yin, Zebrafish heart regeneration and the influence of the epicardium-MCBI
2-6PM Lab: zebrafish heart regeneration
axolotl experiments
Imaging
6-7PM Dinner-Dining Hall
July 29, 2019 Monday
9-10AM Pit talk, James Godwin, Axolotl heart regeneration and immune response—MCBI
10-12PM Lab: Axolotl heart injury
Image zebrafish hearts; section hearts
12-1PM Lunch-Dining Hall
1-4PM Lab: axolotl experiments
4-5PM Goss Lecture: Malcolm Maden: “Discovering the Secrets of Scar-free Healing and Tissue Regeneration”—Maren Auditorium
5-6PM Speaker Reception—Maren Foyer
6-8PM Dinner with Dr. Maden-Dining Hall
Discussion Point: Scarring and aging
July 30, 2019 Tuesday
4:00AM Sunrise and coffee on Cadillac mountain
11-noon Pit Talk, Voot Yin, Zebrafish appendage regeneration and microRNA control—MCBI
12-1PM Lunch
1-2PM Pit Talk, Ben King, Noncoding RNAs and regulatory circuits—MCBI
2-6PM Lab: Decoding the roles of noncoding RNAs-bioinformatics approach; lncRNAs
zebrafish appendage regeneration
Axolotl regeneration
Continuation of other experiments
6-7PM Dinner
July 31, 2019 Wednesday
9-noon Status update on regeneration experiments
Think tank-identifying the important questions—MCBI
12-1PM Lunch
1-6PM Lab: Check in on experiments as needed
Histology of tissue sections
Combing web databases for conserved genetic programs; molecular analysis, RNAseq, bioinformatics
Status update on axolotl experiments, planaria RNA
6-7PM Dinner
7-9PM Regeneration review – updates on hydra, axolotls, planaria and zebrafish—MCBI
August 1, 2019 Thursday
9-noon Free Time: Explore on your own
12-1PM Lunch
3-6PM Lab: EKG analysis of heart function
Zebrafish Imaging
Axolotl heart analysis
4-5PM Public Lecture: Nadia Rosenthal, “Regenerative Medicine and the End of Aging” —Maren Auditorium
5-6PM Speaker Reception—Maren Foyer
6-8PM Dinner with Dr. Rosenthal—Dining Hall
Discussion point: Immune system and impact on decline in cardiac regeneration during aging
August 2, 2019 Friday
9-noon Lab: tissue collection and wrap-up of experiments
12-6PM FREE TIME: Explore on your own
6-10PM Lobster bake dinner celebration, Emery Cove Beach, weather permitting
Faculty tales of past trainees and famous failures
August 3, 2019 Saturday
9-noon Departure, housing units must be vacated by 9am. Luggage can be stored in the dining hall while you wait for ground transport to the airport.
On-Campus Housing
Cottage-style accommodations are assigned double occupancy. Cottage accommodations have shared bathrooms, equipped kitchens, common rooms, high speed wireless internet, and parking. Cottages may be ocean-view, pond-view, or meadow-view.
A few dormitory-style accommodations may be available, double occupancy with shared bathrooms.
A very limited number of single occupancy rooms may be available for an additional charge.