With recent advances in our understanding of both Aging and Stem cells, the objective of this workshop is to present new research on Aging and Stem cells and build bridges between these two disciplines. This workshop is focused on fellows and research trainees, the next generation of investigators, and aims to promote scientific exchange and online discussion between established investigators and research fellows to generate new ideas and approaches to understanding and treating aging-related tissue failure. At the intersection of the aging and stem cell fields, important questions have emerged such as:
- How does aging affect stem cell quiescence, self-renewal, and preservation of a reserve organ progenitor cell population?
- How does aging cause aberrant activation of stem cells that can result in increased vulnerability of stem cells to damage?
- How does aging result in skewing of stem cell fates and failure to restore normal tissue and cell patterning?
- Are aging related deficits caused by changes in stem cells themselves or in the tissues that support their quiescence and activation (the niche)?
- Can we intervene to preserve stem cell homeostasis and extend health and lifespan?
Keynote Speaker: Len Zon, Boston Children’s Hospital
NIH Presentation: Candace Kerr
Registration for this online meeting is free.
Abstract and poster submission deadline is July 16, 2021
Registration Deadline is July 16, 2021
- Courtney (Kozul) Horvath, Ph.D.Global Head of Strategy, Planning & Operations, Translational MedicineNovartis Institutes for BioMedical Research
- Iain Drummond, Ph.D.Professor and Director, Davis Center for Aging and RegenerationMDI Biological Laboratory
- Jonathan Epstein, M.D.Executive Vice Dean and Chief Scientific OfficePerelman School of Medicine
- Aric Rogers, Ph.D.Associate ProfessorMDI Biological Laboratory
- Clifford J. Rosen, M.D.Director, Center for Clinical & Translational ResearchMaine Medical Center Research Institute
- Amar Sahay, Ph.D.Principal Investigator, Associate Professor, Principal FacultyHarvard Stem Cell Institute
- Leonard Zon, M.D.Director of the Stem Cell ProgramChildren's Hospital Boston
Friday July 23, 2021
(all times ET)
- 11:00 – 11:05 AM Welcome and introduction: Iain Drummond & Aric Rogers (MDIBL)
Fellows talks: Cell signaling and Aging
- 11:05 – 11:25 AM Cheng Shi (Department of Molecular Biology, Princeton University)
The piRNA pathway-mediated Hedgehog signaling encodes a germline-to-soma pro-aging signal
- 11:25 – 11:45 AM Hande Sahin (University of Massachusetts Boston)
The effects of aging on wound closure and limb regeneration in the axolotl
Impact of Tissue Environment on Aging:
- 11:45 – 12:05 PM Sri Kidambi (Associate Professor, University of Nebraska)
Stiffness induces aging-like phenotypic changes in microglia
Lunch Break 12:05 – 1:00 PM
- 1:00 – 2:00 PM Candace Kerr, Program Officer at National Institute on Aging
- 2:00 – 2:40 PM Amar Sahay (Center for Regenerative Medicine, MGH/Harvard stem cell Institute / Harvard University)
Overview lecture: Adult hippocampal neurogenesis and aging
Fellows talks: Aging and Neural Stem Cells
- 2:40 – 3:00 PM Chris Morrow (Department of Neuroscience, University of Wisconsin)
Aggresome mediated neural stem cell quiescence exit
- 3:00 – 3:20 PM Cinzia Vicidomini (Center for Regenerative Medicine, MGH/Harvard University)
The role of a neuronally secreted phospholipase in maintaining cognition during aging
- 3:20 – 3:40 PM Lucia Capano (Department of Developmental Biology, Washington University School of Medicine)
Recapitulation of endogenous 4R tau expression analogous to the adult brain in directly reprogrammed human neurons
- 3:40 – 4:00 PM Tyson Joel Ruetz (Wu Tsai Neurosciences Institute, Stanford University)
Disrupting glucose metabolism rejuvenates neural stem cells in the aged brain
- 4:00 – 4:45 PM Leonard Zon (Boston Children’s Hospital and Dana-Farber Cancer Institute; Department of Stem Cell and Regenerative Biology, Harvard University; Howard-Hughes Medical Institute; Harvard Medical School; Harvard Stem Cell Institute)
Stem Cell Clonality and the Niche
- 4:45 – 4:50 PM Concluding remarks and meeting end.
This conference is supported by a grant from the National Institute on Aging (R13AG069520).