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Polyploidy in Organ Development, Repair, and Disease

Location: MDI Biological Laboratory (travel information)

Polyploidy is a conserved and frequently occurring phenomenon whose impact on organismal health and disease is poorly understood. There is currently no meeting that brings together researchers studying polyploidy, despite its increasing prevalence in biology. This symposium will be the first of its kind to focus on polyploidy, bringing together researchers working on a wide range of model systems-plants, fruit flies, mice, yeast and others. Symposium topics will include cell cycle and growth regulation, cell fusion, genome instability, as well as disease models and tissue repair.

We hope that you will join us for this unique opportunity to integrate multiple research perspectives and disciplines, identify new collaborative opportunities, and directions for the emerging areas of polyploid research.

The symposium will be held at MDI Biological Laboratory in Bar Harbor, Maine during peak foliage season.  The magnificent ocean-front campus is located five minutes from Acadia National Park.  Mount Desert Island also offers stunning panoramic views, cycling and hiking paths, canoeing, kayaking, and swimming.

 

Fees

Registration Fee:

Maine GSBSE Students: $275.00
Maine GSBSE Faculty: $325.00
All other Students and PostDocs: $325.00
All others: $400.00

Registration and Abstract Submission Deadlines:

Abstracts are still being accepted for the poster session

Registration deadline: September 15, 2018

(Late registrations will be accepted on a space available basis.)

Partners

Archon ScientificThe Company of Biologists

Schedule as of 9/14/18

Friday, October 12th, 2018 

4-7pm: Campus Housing Check-in

5-7pm: Registration

5-7pm: Drinks and Light Bites served

Saturday, October 13th, 2018 

8:30am: Welcome (Organizers)

Session I: Polyploidy in Organ Development

chaired by Jared Nordman, Vanderbilt University

8:45am- Bernhard Kuhn, Associate Professor at University of Pittsburgh School of Medicine

Formation of bi- and multi-nucleated heart muscle cells in mammals

9:15am- Nora Peterson, Graduate student at Duke University

Syncytium formation in the developing fruit fly rectal papillae

9:30am- Adrienne Roeder, Associate Professor at Cornell University

Fluctuations of the transcription factor ATML1 control the pattern of endoreduplication versus mitosis in the Arabidopsis sepal epidermis

10:00am- Wu-Min Deng, Professor at Florida State University

Mechanic regulation of cell ploidy plasticity in the Drosophila follicular epithelium

10:15am- Jeff Doyle, Professor Cornell University

How does polyploidy generate evolutionary novelty?

10:30am- Coffee Break

11:00am-  Keynote: David Pellman, HHMI Professor at Dana Farber Cancer Institute/ Harvard Medical School

The consequences of whole genome duplication

12:00-1:30pm- Lunch

1:30-3:00pm Poster session/ Reception (coffee & dessert)

Session II: Polyploidy in Tissue Repair and Regeneration

chaired by Don Fox, Duke University

3:30pm- Hao Zhu, Assistant Professor at University of Texas Southwestern Medical Center

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

4:00pm- Jingli Cao, Assistant Professor at Weill Cornell

Tension creates an endoreplication wavefront that leads regeneration of epicardial tissue

4:15pm- Kayla Gjelsvik, Graduate Student at MDI Biological Laboratory

The mechanics of polyploidy in wound repair

4:30pm-Juan Manuel Gonzalez-Rosa, Postdoctoral Fellow at MGH, Harvard Medical School Myocardial Polyploidization creates a barrier to heart regeneration in zebrafish

4:45pm Erez Cohen, Graduate Student at Duke University

A switch from compensatory proliferation to wound-induced polyploidization in the injured Drosophila hindgut 

5:00-6:30pm- Lobster Banquet Dinner

Session III: Cell cycle and Chromosome segregation fidelity

chaired by Meleah Hickman, Emory University

7:00pm-  John Larkin, Professor at Louisiana State University

The Function and roles of the SMR family of plant CDK inhibitors in plant endoreplication and development

7:30pm- Jared Nordman, Assistant Professor at Vanderbilt University

Rif1 inhibits replication fork progression and controls copy number in polyploid cells

7:45pm- Kristin Knouse, Fellow at Whitehead Institute

Tissue architecture is required for chromosome segregation fidelity in hepatocytes

8:00pm-Brian Calvi, Associate Professor, Indiana University

The status of a CDK1 – Myb – Aurora B network determines the choice between mitotic cycles and polyploid endoreplication cycles.

8:15pm- Ryota Uehara, Faculty of Advanced Life Science, Hokkaido University

Novel link between ploidy and centrosome duplication

8:30pm- Open Poster viewing, dessert bar and drinks

Sunday, October 14th, 2018 

8:30am: Opening Remarks (Organizers)

Session IV: Size Control

chaired by Adrienne Roeder, Cornell University

8:45am- Allan Spradling, HHMI Professor at Carnegie Institution for Science

Genomic stability during polyploidization

9:15am- Jeremy Coate, Assistant Professor at Reed College

Ploidy and size in the Arabidopsis sepal

9:30am- Mara Schvarzstein, Assistant Professor at City University of New York, Brooklyn College

New multicellular animal system C. elegans:  effects of genome copy number on the size and scaling relationships of biological structures

9:45am- Mary Baylies, Professor at Memorial Sloan Kettering Cancer Center

Cell size and nuclear scaling relationships in multinucleated muscle fibers

10:00am- Coffee Break

Session V: Polyploidy in Infection and Disease

chaired by Vicki Losick, MDI Biological Laboratory

10:30am- Janice de Almeida, Professor at Institut National de la Recherche Agronomique

The endocycle plays a key role on feeding sites induced in host plants by obligate sedentary parasitic root-knot nematodes

11:00am-Shyama Nandakumar, Graduate student at University of Michigan

Polyploidy in the ageing Drosophila melanogaster brain

11:15am- Meleah Hickman, Assistant Professor at Emory University

Virulence of a fungal pathogen depends on pathogen ploidy and host immune status

11:30am- Erin Bailey, Graduate student at University of Maine

Determining the causes of disease variability in a zebrafish muscular dystrophy model

11:45am-Héctor Herranz, Associate Professor at Institute of Cecllular and Molecular Medicine

A fly approach to cytokinesis failure and tumorigenesis

12:00pm Lunch

1:00pm DEPART

                 

 

 

 

A group rate room block has been reserved at the Acadia Park Inn (Best Western). The hotel is 0.7 miles from campus. The double queen room rate of $185/night is 15% off standard rates and includes a continental breakfast buffet. Contact the hotel and ask for the Polyploidy Conference rate – 207-288-5823. The rate expires September 1, 2018.

On-campus double occupancy dormitory-style housing may be reserved for an additional fee. Friday and Saturday nights only, $218.00 total. Reservations are made through the reservation form on a first-come first-serve basis until all rooms are filled.

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