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Comparative Biology of Tissue Repair, Regeneration, and Aging Symposium 2015

Kathryn W. Davis Center for Regenerative Biology and Medicine
Location: MDI Biological Laboratory (travel information)
Comparative Regenerative Biology model organisms

Read the report from this Symposium published in Nature Partner Journal Regenerative Medicine

This symposium brought together scientists seeking to understand the determinants of regenerative capacity, the causes of biological aging, and strategies for applying what is learned from such research to improve human health and advance regenerative medicine.

Keynote Address: Restoring Movement after Paralysis: A Clinical Success Story Claudia Angeli Ph.D. and Dustin Shillcox

MDI Biological Laboratory is located next to Acadia National Park and Bar Harbor on Mount Desert Island, Maine.

This symposium was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM104318.

Partners

MDI Biological Laboratory COBRE: Comparative Biology of Tissue Repair, Regeneration, and AgingUnion Biometrica
Friday, June 26, 2015
3:00 – 5:00p Registration and Poster Set-up (Maren Conference Center)
5:00 – 6:00p Dinner (Dining Hall)
6:00 – 7:00p Keynote Address (Maren Conference Center)
Introduction: Dustin Updike, Ph.D., Assistant Professor, MDI Biological LaboratoryRestoring Movement after Paralysis: A Clinical Success Story, Claudia Angeli Ph.D., University of Louisville, and Dustin Shillcox
7:00 – 9:00p Evening Reception (Maren Conference Center)
Saturday June 27, 2015
7:00 – 8:15a Breakfast (Dining Hall)
8:30 – 12:00p Morning Session: Comparative Biology of Aging and Regeneration
Maren Conference Center
Chair: Aric Rogers, Ph.D., Assistant Professor, MDI Biological Laboratory
8:30 – 9:00a Steven Austad, University of Alabama at Birmingham: The uses of species with exceptional longevity
9:00 – 9:30a Ashley Seifert, University of Kentucky: Comparative biology of vertebrate regeneration
9:30 – 10:00a Itamar Harel, Stanford University: The African killifish: a model for vertebrate aging
10:00 – 10:15a Break
10:15 – 10:45a Richard Morimoto, Northwestern University: The biology of proteostasis in aging and disease
10:45 – 11:15a Phillip Newmark, University of Illinois at Urbana-Champaign: Germ cell development and regeneration in planarians: implications for understanding parasitic flatworms
11:15 – 11:30a Brigitte Galliot, University of Geneva: Deficiency in epithelial plasticity drives loss of regeneration and aging in hydra
11:30 – 11:45a Andrea Bodnar, Bermuda Institute for Science: Tissue homeostasis, regeneration and negligible senescence: insight from sea urchins
11:45 – 12:00p Vicki Losick, Carnegie Institution for Science: Going big for wound repair
12:00 – 1:30p Lunch (Dining Hall)
1:30 – 5:00p Afternoon Session: Determinants of Regenerative Capacity
Maren Conference Center
Chair: Jim Coffman, Ph.D., Associate Professor, MDI Biological Laboratory
1:30 – 2:00p Eric Olson, University of Texas Southwestern: A unique twist-2 dependent myogenic progenitor cell lineage contributes to skeletal muscle growth, homeostasis and regeneration
2:00 – 2:30p Thomas Rando, Stanford University: Molecular regulation of stem cell quiescence and activation
2:30 – 3:00p Jonathan Epstein, University of Pennsylvania: Immune regulation of tissue regeneration
3:00 – 3:15p Break
3:15 – 3:45p Leanne Jones, University of California at Los Angeles: Gut instincts: using the intestine as a model to explore the effects of aging on stem cells and the niche
3:45 – 4:15p Dustin Updike, MDI Biological Laboratory: Germ granules and the maintenance of cellular totipotency
4:15 – 4:30p Jennifer Simkin, University of Kentucky: Macrophage phenotype reveals fundamental differences between regeneration and scarring
4:30 – 4:45p Jeremy Ng, Australian Regenerative Medicine Institute: Environmental cues direct fate specification during zebrafish retinal regeneration
4:45 – 5:00p Benjamin King, MDI Biological Laboratory: Comparative models of regeneration database (RegenDB)
5:00 – 6:00p Poster Session (Maren Conference Center)
6:00 – 7:00p Panel Discussion: Translating Results to Clinical Applications (Maren Conference Center)
Moderated by Voot P. Yin, Ph.D., Assistant Professor, MDI Biological Laboratory.
Panelists:
7:00 – 7:30p Reception
7:30 – 9:00p Lobster Banquet (Dining Hall)
Sunday June 28, 2015
7:00 – 8:15a Breakfast (Dining Hall)
8:30 – 12:00p Morning Session: Stress and Stress Signaling in Aging and Regeneration
Maren Conference Center
Chair: Dustin Updike, Ph.D., Assistant Professor, MDI Biological Laboratory
8:30 – 9:00a Steven Houser, Temple University: Cortical bone stem cells for cardiac repair
9:00 – 9:30a Sandra Rieger, MDI Biological Laboratory: IKKα serves as an innate surveillant for hydrogen peroxide-dependent wound re-epithelialization
9:30 – 10:00a Nadia Rosenthal, Australian Regenerative Medicine Institute and The Jackson Laboratory: Immune regulation of regeneration
10:00 – 10:15a  Break
10:15 – 10:30a James Coffman, MDI Biological Laboratory: Cortisol-treated zebrafish embryos develop a pro-inflammatory adult phenotype with reduced regenerative capacity
10:30 – 10:45a Helena Reinardy, Bermuda Institute of Ocean Science: Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers
10:45 – 11:00a Kailin Mesa, Yale University: Niche-induced cell death limits the hair follicle stem cell pool
11:00 – 11:15a Jarod Rollins, MDI Biological Laboratory: Alternative splicing and NMD increase lifespan under dietary restriction by post-transcriptionally suppressing expression of ribosomal subunits
11:15a Meeting adjourns

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