
Read the report from this Symposium published in Nature Partner Journal Regenerative Medicine
This symposium brought together scientists seeking to understand the determinants of regenerative capacity, the causes of biological aging, and strategies for applying what is learned from such research to improve human health and advance regenerative medicine.
Keynote Address: Restoring Movement after Paralysis: A Clinical Success Story Claudia Angeli Ph.D. and Dustin Shillcox
MDI Biological Laboratory is located next to Acadia National Park and Bar Harbor on Mount Desert Island, Maine.
This symposium was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM104318.
- James A. Coffman, Ph.D.Associate Professor; Director, Maine IDeA Network of Biomedical Research Excellence (INBRE)MDI Biological Laboratory
- Benjamin L. King, Ph.D.Assistant Professor of BioinformaticsUniversity of Maine
- Aric Rogers, Ph.D.Associate ProfessorMDI Biological Laboratory
- Dustin Updike, Ph.D.Associate ProfessorMDI Biological Laboratory
Friday, June 26, 2015 | |
3:00 – 5:00p | Registration and Poster Set-up (Maren Conference Center) |
5:00 – 6:00p | Dinner (Dining Hall) |
6:00 – 7:00p | Keynote Address (Maren Conference Center) Introduction: Dustin Updike, Ph.D., Assistant Professor, MDI Biological LaboratoryRestoring Movement after Paralysis: A Clinical Success Story, Claudia Angeli Ph.D., University of Louisville, and Dustin Shillcox |
7:00 – 9:00p | Evening Reception (Maren Conference Center) |
Saturday June 27, 2015 | |
7:00 – 8:15a | Breakfast (Dining Hall) |
8:30 – 12:00p | Morning Session: Comparative Biology of Aging and Regeneration Maren Conference Center Chair: Aric Rogers, Ph.D., Assistant Professor, MDI Biological Laboratory |
8:30 – 9:00a | Steven Austad, University of Alabama at Birmingham: The uses of species with exceptional longevity |
9:00 – 9:30a | Ashley Seifert, University of Kentucky: Comparative biology of vertebrate regeneration |
9:30 – 10:00a | Itamar Harel, Stanford University: The African killifish: a model for vertebrate aging |
10:00 – 10:15a | Break |
10:15 – 10:45a | Richard Morimoto, Northwestern University: The biology of proteostasis in aging and disease |
10:45 – 11:15a | Phillip Newmark, University of Illinois at Urbana-Champaign: Germ cell development and regeneration in planarians: implications for understanding parasitic flatworms |
11:15 – 11:30a | Brigitte Galliot, University of Geneva: Deficiency in epithelial plasticity drives loss of regeneration and aging in hydra |
11:30 – 11:45a | Andrea Bodnar, Bermuda Institute for Science: Tissue homeostasis, regeneration and negligible senescence: insight from sea urchins |
11:45 – 12:00p | Vicki Losick, Carnegie Institution for Science: Going big for wound repair |
12:00 – 1:30p | Lunch (Dining Hall) |
1:30 – 5:00p | Afternoon Session: Determinants of Regenerative Capacity Maren Conference Center Chair: Jim Coffman, Ph.D., Associate Professor, MDI Biological Laboratory |
1:30 – 2:00p | Eric Olson, University of Texas Southwestern: A unique twist-2 dependent myogenic progenitor cell lineage contributes to skeletal muscle growth, homeostasis and regeneration |
2:00 – 2:30p | Thomas Rando, Stanford University: Molecular regulation of stem cell quiescence and activation |
2:30 – 3:00p | Jonathan Epstein, University of Pennsylvania: Immune regulation of tissue regeneration |
3:00 – 3:15p | Break |
3:15 – 3:45p | Leanne Jones, University of California at Los Angeles: Gut instincts: using the intestine as a model to explore the effects of aging on stem cells and the niche |
3:45 – 4:15p | Dustin Updike, MDI Biological Laboratory: Germ granules and the maintenance of cellular totipotency |
4:15 – 4:30p | Jennifer Simkin, University of Kentucky: Macrophage phenotype reveals fundamental differences between regeneration and scarring |
4:30 – 4:45p | Jeremy Ng, Australian Regenerative Medicine Institute: Environmental cues direct fate specification during zebrafish retinal regeneration |
4:45 – 5:00p | Benjamin King, MDI Biological Laboratory: Comparative models of regeneration database (RegenDB) |
5:00 – 6:00p | Poster Session (Maren Conference Center) |
6:00 – 7:00p | Panel Discussion: Translating Results to Clinical Applications (Maren Conference Center) Moderated by Voot P. Yin, Ph.D., Assistant Professor, MDI Biological Laboratory. Panelists:
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7:00 – 7:30p | Reception |
7:30 – 9:00p | Lobster Banquet (Dining Hall) |
Sunday June 28, 2015 | |
7:00 – 8:15a | Breakfast (Dining Hall) |
8:30 – 12:00p | Morning Session: Stress and Stress Signaling in Aging and Regeneration Maren Conference Center Chair: Dustin Updike, Ph.D., Assistant Professor, MDI Biological Laboratory |
8:30 – 9:00a | Steven Houser, Temple University: Cortical bone stem cells for cardiac repair |
9:00 – 9:30a | Sandra Rieger, MDI Biological Laboratory: IKKα serves as an innate surveillant for hydrogen peroxide-dependent wound re-epithelialization |
9:30 – 10:00a | Nadia Rosenthal, Australian Regenerative Medicine Institute and The Jackson Laboratory: Immune regulation of regeneration |
10:00 – 10:15a | Break |
10:15 – 10:30a | James Coffman, MDI Biological Laboratory: Cortisol-treated zebrafish embryos develop a pro-inflammatory adult phenotype with reduced regenerative capacity |
10:30 – 10:45a | Helena Reinardy, Bermuda Institute of Ocean Science: Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers |
10:45 – 11:00a | Kailin Mesa, Yale University: Niche-induced cell death limits the hair follicle stem cell pool |
11:00 – 11:15a | Jarod Rollins, MDI Biological Laboratory: Alternative splicing and NMD increase lifespan under dietary restriction by post-transcriptionally suppressing expression of ribosomal subunits |
11:15a | Meeting adjourns |