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Polyploidy in Development, Evolution, and Disease
Polyploidy is a conserved and frequently occurring phenomenon whose impact on organismal health and disease is poorly understood. This is the second symposium at MDI Biological Laboratory designed to bring together researchers studying polyploidy.
- October 6-8, 2021
- Virtual Symposium
Application Deadline: 10/03/2021
Overview
This symposium will build on the 2018 event to bring together researchers working on a wide range of model organisms; plants, fruit flies, mice, yeast and others. Symposium topics will include cell cycle and growth regulation, cell fusion, genome instability, as well as disease models and tissue repair.
Keynote Speaker: Rebecca Heald, Ph.D., UC Berkeley
We hope that you will join us for this unique opportunity to integrate multiple research perspectives and disciplines, identify new collaborative opportunities, and directions for the emerging areas of polyploid research. Abstracts will be accepted for short talk or poster presentations. Submission deadline is July 15, 2021. Abstracts are submitted through the registration process.
Fees
$50 USD Group leaders/PIs
$25 USD Students and staff
Organizers
Brian Calvi, Ph.D. Professor
Indiana University BloomingtonMara Schvarzstein, Ph.D. Assistant Professor
City University of New York BrooklynE. Han Tan, Ph.D. Assistant Professor
University of MaineInvited Speakers
Gustavo Leone, Ph.D. Director
Medical College of Wisconsin Cancer CenterLaura Buttitta, Ph.D. Associate Professor
University of MichiganMichael Barker, Ph.D. Associate Professor
University of ArizonaRebecca Heald, Ph.D. 2021 Polyploidy Symposium Keynote; Flora Lamson Hewlett Chair and Professor of Cell and Developmental Biology
University of California, BerkeleyWallace Marshall, Ph.D. Professor
University of California, San FranciscoZuzana Storchova, Ph.D. Professor of Molecular Genetics
University KaiserslauternProgram
October 6:
11:00 – 11:05 AM Welcome and introduction: Brian Calvi (Indiana University Bloomington)
I. Polyploidy in Evolution, Ecology
11:05 – 11:30 AM Michael Barker (University of Arizona) Variation in polyploidy across the tree of life
11:30 – 11:45 AM Short Talk: Marek Glombik (Czech Academy of Sciences) Stable patterns of genome dominance in reciprocal grass hybrids (Festuca × Lolium) revealed by k-mer based approach
II. Polyploid cell cycle and gene expression
11:45 – 12:00 PM Short Talk: Simon Gemble (Institut Curie) To scale or not to scale: G1 phase duration does not scale up with DNA content in polyploid cells generating genome reshuffling
12:00 – 12:25 PM Zuzana Storchova (University Kaiserslautern) Scaling of gene expression in budding yeasts of different ploidy
Break/Poster session 12:25 – 1:30 PM
III. Polyploid cell division
1:30 – 1:55 PM Kirsten Bomblies (ETH Zürich) Learning a tango of four – Meiotic adaptation to whole genome duplication via “supercharged” crossover interference
1:55 – 2:10 PM Short Talk: Elvira Hoerandl (University of Goettingen) Effects of polyploidy on stress response and loss of sex in plants
2:10 – 2:25 PM Short Talk: Manon Budzyk (Institut Curie) Mitotic nucleases: dangerous actors in asynchronous polyploid cells
2:25 – 2:50 PM Don Fox (Duke University) How to survive polyploid mitosis
2:50 – 3:00 PM Day’s wrap up: E. Han Tan (University of Maine)
October 7:
11:00 – 11:05 AM Introduction to Day 2: Mara Schvarzstein (City University of New York Brooklyn)
IV. Polyploid Nuclear, Cell, and Tissue Scaling
11:05 – 12:00 PM Keynote: Rebecca Heald (University of California at Berkeley) Amphibians with different genome sizes facilitate investigation of size scaling and speciation
12:15 – 12:30 PM Short Talk: Jozefien Van de Velde (Max Planck Institute for Plant Breeding Research) Population genomics of Australian burrowing frogs Neobatrachus reveal adaptation to polyploidy
12:30 – 12:45 PM Short Talk: Dongying Gao (United States Department of Agriculture) Development of synthetic allotetraploids for enhancing peanut disease resistance and genome evolution
Break/Poster session 12:45 – 1:30 PM
IV. Polyploid Cell, Nuclear, and Tissue Scaling, cont.
1:30 – 1:55 PM Adrienne Roeder (Cornell University) Arabidopsis leaf and sepal sizes compensate for increased cell size due to polyploidy
1:55 – 2:10 PM Short Talk: Xavier Franch Marro (Institute of Evolutionary Biology at UPF-CSIC) Ploidy levels regulate cell fate during metamorphosis in Drosophila melanogaster
2:10 – 2:25 PM Short Talk: Stefanie Windner (Memorial Sloan Kettering Cancer Center) Scaling of nuclear sizes and DNA content in multinucleated muscle fibers
2:25 – 2:50 PM Wallace Marshall (University of California at San Francisco) Dynamics of nuclear shape in Stentor
2:50 – 3:00 PM Day’s wrap up: Mara Schvarzstein
October 8:
11:00 – 11:05 AM Introduction to Day 3: Brian Calvi
V. Polyploidy in Tissue Development and Regeneration
11:05 – 11:30 AM Laura Butitta (University of Michigan) Cell Cycle Re-entry in Postmitotic Tissues
11:30 – 11:45 AM Short talk: Alberto Gandarillas (Insituto de Investigación Maqués de Valdecilla) Mitotic slippage and polyploidisation automatically control mammalian epidermal homeostasis
11:45 – 12:00 PM Short Talk: Cara Gottardi (Northwestern University Feinberg School of Medicine) Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration
12:00 – 12:25 PM Vicki Losick (Boston College) Endocycle restores tissue tension in Drosophila abdomen post wound repair
Break/Open conversation 12:25 – 1:15 PM
VI. Polyploidy in Genome Instability and Disease
1:15 – 1:40 PM Gustavo Leone (Medical College of Wisconsin) Title TBA
1:40 – 1:55 PM Short Talk: Valentina Sladky (Johns Hopkins University School of Medicine) The centriole-PIDDosome pathway restricts hepatocyte polyploidization to facilitate regeneration following chronic liver injury
1:55 – 2:10 PM Short Talk: Kelly Hartsough (Indiana University at Bloomington) Induced endoreplication by Aurora B kinase inhibition as a model for tumor heterogeneity
2:10 – 2:35 PM Wu-Min Deng (Tulane University School of Medicine) Polyploid mitosis, depolyploidization and chromosomal instability in a Drosophila tumor model
2:50 – 3:00 PM Concluding remarks and meeting end: Brian Calvi