MDI Biological Laboratory

Topic: Bioinformatics

Data Science Team Explores New Protein Functions

Data Science Core Director Joel Graber, Ph.D., and several of his MDI Bio Lab Core team are co-authors of a new publication in Genetics that details previously undescribed molecular and genetic functions of a protein in yeast that is conserved in humans.

Continue Reading

Cloud Computing 101

Joel Graber, Ph.D., is a Senior Staff Scientist and Director of the Computational Biology and Bioinformatics Core, funded by a Center of Biomedical Research Excellence award from the National Institutes of Health 

Continue Reading

Bioinformatics: The Importance of Training the Trainer

In recent years bioinformatics – using computational power to help process the massive swathes of data produced by modern experiments – has become an indispensable tool for research scientists.

Continue Reading

MINOTA 2020 – a change of direction

Transcriptome-profiling is the primary means by which researchers characterize what is happening at the molecular level.  When a transcriptome profile is generated for a sample, it tells us which genes are active (being expressed) and at what amount.  Comparing profiles among samples allows us to identify genes, and importantly the biological processes that are varying...

Continue Reading

Part III: Meet the Computational Biology Core

(Read part one or part two of the series.)  For this entry into our ongoing discussion of the MDI Biological Laboratory Computational Biology Core, I want to take a step back and, rather than talk about the specifics of the science, instead talk about who we are, what we do, and why it is so...

Continue Reading

Bioinformatics Part II: What do my genome-scale measurements of gene expression mean?

Graphical representation of differential gene expression for a single gene.  The red triangles represent measurements of replicate treated samples, and the black diamonds represent matched control samples.  Differential expression of this gene is determined by a statistical analysis of the separation between expression levels in treated and control, compared to the variation within each group...

Continue Reading

Part I: Computational Biology is vital to modern research

But what exactly is it and why does science need it? The typical interpretation of this figure is that the arrows represent the “flow of information”: that DNA is capable of self-replication (represented by the circular arrow); that the information stored in DNA is activated by first being transcribed to RNA (resulting in an RNA...

Continue Reading

Big Data: Computational Biology Opens a New Window on the World’s Challenges for Colby Scientists

In this excerpt from an article in Colby Magazine by Kate Carlisle, genomics expert Andrea R. Tilden, Ph.D., The J. Warren Merrill Associate Professor of Biology at Colby and a visiting scientist in bioinformatics at the MDI Biological Laboratory, discusses the evolution of the fields of bioinformatics and computational biology.

Continue Reading