MDI Biological Laboratory

Topic: Aging

HoL1day Tree

Hannah Somers, a research assistant in the Rollins lab, created this composite image of L1 C. elegans. C. elegans have four larval stages before adulthood – L1 is the first larval stage after hatching. These images were taken to understand how intermittent fasting impacts L1 C. elegans and protein translation rates. L1 C. elegans enter an ageless state of arrest when fasted, making…

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Tiny Worlds, Big Science: MDIBL Scientists See Deeper Inside the Cell

MDI Biological Laboratory’s Emily Spaulding, Ph. D., is using advanced “super-resolution” microscopy to peer deep within the active cells of a tiny, transparent roundworm called C. elegans. What she’s found there is a powerful new tool for studying the functions of a common gene protein called Nucleolin. And the work offers a challenge to some…

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Beyond the Naked Eye

My interest in microscopy started when I was young – I loved small critters like bugs, worms, and all manner of things you can find under a rock. My grandfather sent us a small microscope to use, and I spent hours looking at my little treasures with it. As I got older, I developed a…

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Comparative Biology: Animal Models Strut Their Stuff

  At MDIBL, researchers are particularly focused on the mechanisms of aging and regeneration. Non-mammalian model organisms like C. elegans, zebrafish, African turquoise killifish, and the axolotl regenerate naturally in ways that humans cannot. By decoding the instruction manual for their regenerative abilities, we can develop new strategies to enhance our natural ability to repair…

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New Research by Aric Rogers, Ph.D., Sheds Light on the Effects of Dietary Restriction on Muscle Tissue

Consider the following scenarios: In the first, a thin young woman who exercises excessively develops athletic amenorrhea, or stops menstruating, rendering her incapable of bearing children. In the second, a sedentary, overweight girl undergoes menarche at a precociously early age. Aric N. Rogers, Ph.D., who studies aging at the MDI Biological Laboratory, believes these scenarios…

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Meet Our Postdocs: Dilawar Mir, Ph.D.

The pull of C. elegans drew Dilawar Mir, Ph.D. to the Rogers Lab at the MDI Biological Laboratory for his postdoctoral research. Born and raised in the Kashmir Valley, Mir earned his Ph.D. from Alagappa University in India in 2019. His graduate research focused on understanding host-pathogen interactions in the context of the whole organism;…

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Meet Our Postdocs: Zhengxin Ma, Ph.D.

Zhengxin first encountered C. elegans during her graduate studies at the University of Florida, where she earned a M.S. in animal nutrition and a Ph.D. in animal microbiology, studying how to mitigate antimicrobial-resistant pathogens. She used the model to test the toxicity of bacterial toxins and chemicals and was hooked. When it came time to…

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Meet Our Postdocs: Jun-Yeong Lee, Ph.D.

During Dr. Jun-Yeong Lee’s graduate career at Seoul National University, he discovered genes in a species of lactic acid bacteria that are responsible for preventing infection in animals, such as livestock. After completing his Ph.D., Jun-Yeong wanted to expand his knowledge of data mining and big data analysis,  and shift his focus to mammals instead…

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Meet Our Postdocs: Hyemin Min, Ph.D.

Hyemin is one of the newest postdoctoral researchers to join the MDI Biological Laboratory, arriving in July 2021 to begin her final stage of scientific training. She hails from Seoul, Korea and completed her master’s and doctoral degrees at Konkuk University of Korea. Under the guidance of her advisor, Professor Yhong-Hee Shim, she studied the…

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