MDI Biological Laboratory
CELEBRATING 120 YEARS OF CUTTING-EDGE SCIENCE ON MAINE'S RUGGED COAST

Pioneering New Approaches in Regenerative Medicine

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Eau: Safe Water Systems = Strong Public Health

  • May 23, 2022
  • 5:00 - 6:00 pm
  • Online
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Blog

Funding Helps Expand Arsenic Awareness Program

Groundwater contaminated with naturally occurring arsenic is one of the most pressing public health issues in Maine and New Hampshire. Since 2016, associate professor of environmental health, Jane...

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MDI Biological Laboratory opens its doors to Ukrainian scientists from the war-torn country

  • April 22, 2022

The MDI Biological Laboratory (MDIBL) is announcing plans to shelter scientists, research personnel, and their families fleeing the war in Ukraine.

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Blog

As Popular As Ever: MBMSS 2022

After two years of virtual events, people were thrilled at this year’s hybrid model, with comments such as: “It felt so good to be back in person and networking with so many engaging and...

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Support Us

Our scientists and students are working hard to develop new approaches to prevent and treat degenerative disease. However, their work would not be possible without your support. Your gift of any...

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Mount Desert Island Biological Laboratory unveils new tracing app as Covid-19 cases rise in Maine and across New England

  • May 10, 2022
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Research Links Age-Related Chronic Inflammation with Disruption of Chromatin Architecture
Research Spotlight

Research Links Age-Related Chronic Inflammation with Disruption of Chromatin Architecture

A research team led by Samuel Beck, Ph.D. has identified disruption of chromatin architecture as the mechanism underlying inflammaging, a chronic, low-grade inflammatory response that has been linked to the chronic diseases of old age, including Alzheimer’s, cancer, diabetes, heart disease, macular degeneration and more, as well as to a shortened lifespan.

While science has long connected a chronic, progressive increase in inflammation with aging, the mechanism by which inflammation leads to aging has been unclear. In a recent paper, Beck demonstrated that this chronic inflammatory status, which has been dubbed “inflammaging,” is caused by disruption of the three-dimensional architecture of the chromatin, which is the part of the cell nucleus containing the chromosomes that carry genetic information in the form of genes.

The majority of Beck’s research was carried out through the large-scale computational analysis of publicly available genomic datasets, a technique that Beck, a computational biologist, calls “extracting knowledge from community wisdom.”

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This Is Why

A Legacy to Nurture Curious Minds

Chuck Dinsmore has devoted his life to curiosity, discovery and fostering a love of science in others. By making a planned estate gift, he has joined the ranks of the John S. Kingsley Society at MDI Biological Laboratory, and ensured that nurturing curiosity in learners of all ages is part of his legacy.

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